Apixaban CAS NO.503612-47-3

• 

• Basic information

  1. Product Name: Apixaban
  2. Synonyms: Apixaban;Apixaban, BMS 562247-01;1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide;BMS 562247-01;1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid aMide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4, 5-dihydropyrazolo[3,4-c]pyridine-3-carboxaMide;Nilotinib and its interMediate
  3. CAS NO:503612-47-3
  4. Molecular Formula: C25H25N5O4
  5. Molecular Weight: 459.504
  6. EINECS: 1308068-626-2
  7. Product Categories: Inhibitor;Inhibitors
  8. Mol File: 503612-47-3.mol

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 770.468 °C at 760 mmHg
  3. Flash Point: 419.764 °C
  4. Appearance: white powder
  5. Density: 1.42
  6. Vapor Pressure: 0mmHg at 25°C
  7. Refractive Index: 1.705
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 15.01±0.20(Predicted)
  11. CAS DataBase Reference: Apixaban(CAS DataBase Reference)
  12. NIST Chemistry Reference: Apixaban(503612-47-3)
  13. EPA Substance Registry System: Apixaban(503612-47-3)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 503612-47-3(Hazardous Substances Data)

         As a high-tech enterprise invested by Nanjing CHICO Pharmaceutical Co., Ltd., Anqing CHICO Pharmaceutical Co., Ltd is mainly engaged in the MAH/CDMO service of APIs and production of high-end pharmaceutical intermediates. Since inception, we have devoted ourselves to the research, development and production of small molecule targeted anti-tumor, anti-diabetic, anti-virus APIs and pharmaceutical intermediates.

         Our company is located in Anqing High-tech Industrial Development Zone (a province-level chemical park of Anhui province), covering an area of 20,000㎡, with two three-storey Class A plant buildings including  6 workshops: 2 of them are used for the manufacturing of High-end pharmaceutical intermediates, and the rest 4 workshops are GMP workshop, which are utilized to provide MAH services.
         We also set an R&D center in  JSLS at No. 9 Weidi Road in Nanjing city, with a total land of 1,800㎡。We have an experienced and energetic R&D team equipped with advanced organic synthesis and analytical testing apparatus. Also we areequipped with the data audit trail system (online version) and ISO9001 quality certificated management system which can help us meet the regulatory requirements for API registration and declaration.
         As patents expire and generic drugs come on the market, some projects have successfully achieved commercial mass production, and new projects will be approved for marketing every 1-2 years which will give power to the sustainable development of our company.
         Through the successful development of tinib, liptin, liflozin and xaban products, our company has established closely cooperative relations with more than 30 of the top-100 pharmaceutical companies in China to help Chinese generic drugs research, development and marketing. In addition, we also vigorously expanded overseas markets, and have established partnerships with some of the top-ten companies in India and passed related supplier qualification audits.
         In 2018, we participated in the 7th China Innovation and Entrepreneurship Competition held by the Ministry of Science and Technology. After the selection of preliminary contest and the rematch of Anqing City and Anhui Province, our company was finally selected into the national finals and won the "Award of Excellent Enterprise".
         Regarding quality as number one priority, we have established a strict quality assurance system reference to GMP requirements. In accordance with the requirements of relevant EHS laws and regulations of China, we also have established a sound EHS management system and strive to create a safe, healthy and clean working environment for our employees to achieve sustainable development.

         Adhering to the business philosophy of "Consummate Service Convincing Honor", we strive to provide quality products and first-class service for customers relying on profound technical accumulation and outstanding professional quality. We sincerely welcome new and old customers at home and abroad to conduct business relations with us. We sincerely look forward to continuously enhancing mutual friendship through honest, high-quality, high- efficient and professional service. We will work with you to create a bright future!